The pioneering spirit leads us and urges us to be inventive, to walk beyond our boundaries and to widen our circles in mission. The signs of the times are complex and interrelated across the world, e.g. the impact of climate change in the area of health with its different facets across the world: greed, poverty, migration, calamities. They ask for global responses. A global vision for MMS mission will help us to determine our priorities for mission across the Society.